One of the biggest fights of the last few years is right around the corner. Canelo Alvarez challenges Miguel Cotto on Saturday, Nov. 21 for his WBC middleweight title, and there’s a good chance the champ will lose his belt.

Alvarez enters the bout having suffered his only career loss to Floyd Mayweather. At 10 years younger than Cotto, the Mexican is expected to outlast the Puerto Rican champ. Alvarez is a -300 favorite at Bovada.lv, hoping to claim his fourth straight victory.

Timothy Bradley and Brandon Rios, two longtime champions and warriors, will square off in a fight that will almost certainly determine the future course of their careers. With both boxers on the edge of big picture relevance, this fight on Nov. 7 at the Thomas & Mack Center in Las Vegas on HBO World Championship Boxing at 9:30 pm ET/PT promises to be as impactful as it will be entertaining.